Dr. Bruce P. Dunn

ACTIVITIES IN THE BIOLOGICAL SCIENCES - UPDATED 2006

 

PREVIOUS POSITION:

Head, Environmental Carcinogenesis Section

Division of Cancer Control Research

B.C. Cancer Agency

600 W. 10th Avenue

Vancouver B.C.  V5Z 4E6

 

 

EDUCATION:

 

1965-1969:        Honours Biochemistry, University of British Columbia

1969:                B.Sc.  Honours Biochemistry, University of British Columbia

                        Thesis:  Biochemical Effects of Vinblastine and Acronycine on L5178Y Cells.

1969-1974:        Ph.D. Program in Biochemistry, University of British Columbia

                        Supervisor:  Dr. C.T. Beer

1974:                Ph.D., University of British Columbia

                        Thesis: Biochemical and Cytological Effects of the Anticancer Alkaloid

                        Acronycine on Tumor Cells in Culture

1974-1977:        Postdoctoral Studies:  Dr. H.F. Stich, Dept. of Zoology, University of British Columbia

 

AWARDS:

1965-1969:        Government of British Columbia:  First Class Mark Fee Awards

1969:                Society of Chemistry and Industry: Gold Key Award

                        First in Graduating Class, Honours Biochemistry, 1969

1969-1972:        National Cancer Institute of Canada Studentships

1972-1974:        National Cancer Institute of Canada Predoctoral Fellowships

1974-1977:        National Cancer Institute of Canada Postdoctoral Fellowships

1977-1983:        Department of Health and Welfare Research Scholar Awards

 

ACADEMIC AND PROFESSIONAL POSITIONS:

1977-1990         Research Associate, Department of Medical Genetics, University of British Columbia

1986-1997         Adjunct Professor, School of Kinesiology, Simon Fraser University

1978-1990         Scientist, Environmental Carcinogenesis Unit, B.C. Cancer Research Center

1990-1996         Head, Environmental Carcinogenesis Section, Division of Epidemiology and Cancer Prevention, British Columbia Cancer Agency

1991-1995         Member, Chemoprevention Section, Eastern Cooperative Oncology Group for Hospitals in the United States (ECOG)

1992-1998         Clinical Associate Professor, Dept. of Health Care and Epidemiology, University of British Columbia

 

SCHOLARLY AND PROFESSIONAL ACTIVITIES

- Panel member, Acid Deposition Research Program: Human Health Effects, 1984

- Member, Subcommittee on Cancer Education in the Workplace, Canadian Cancer Society, B.C. and Yukon Division, 1985-1988

- Member, Carcinogens Committee, Canadian Cancer Society, 1986-1990

- Member, Consumer Advisory Panel, Canadian Standards Association, 1983-1990

- Chairman, Biological and Chemical Hazard Committee, B.C. Cancer Agency, 1990-1995

- Contributor, Space Exploration Outreach Program, NASA, 1990

- Member, Disaster Planning Committee, B.C. Cancer Agency, 1991-present.

- Member, Environmental Science Research Institute, Simon Fraser University, 1991-present

- Member, Strategic Grants Panel for Environmental Quality, NSERC, 1992-1995

- Member, Diet and the Environment Working Group, National Forum on Breast Cancer, 1993

- Member, Expert Panel for evaluation of applications for Networks of Centres of Excellence, 1995

 

INVITED SYMPOSIUM PRESENTATIONS

1.  Symposium: Chemically Contaminated Aquatic Food Resources and Human Cancer Risk, Research Triangle Park, NC, September 29-30, 1988.  Carcinogen Adducts as an Indicator for Public Health Risks of Consuming Carcinogen Exposed Fish and Shellfish

 

2.  Symposium: Toxicology and Exposure Measurement, American College of Toxicology Meeting, Baltimore, MD, October 31-November 2, 1988.  Detection of aromatic DNA adducts in human cells and fish liver.

 

3.  Symposium: In Situ Evaluation of Biological Hazards of Environmental Pollutants, Chapel Hill, NC, December 5-7, 1988. DNA-carcinogen adducts in fish as a tool for measuring the effective biological dose of aquatic carcinogens.

 

4.  Toxicology Forum, Aspen CO, July 16-20 1990.  DNA-Adducts: Environmental Exposures.

 

RESEARCH INTERESTS

Primary prevention of cancer by dietary and lifestyle modifications

Diet and lifestyle factors affecting the recurrence rate of cancer in patients who have received primary treatment.

Role of carotenoids and retinoids in tumor prevention.

Active oxygen damage and its role in tumor initiation and tumor promotion.

Strategies for dissemination of public information about cancer risks and alternate cancer therapies.

 

 

PUBLICATIONS

Full-length papers:

 

1.         Gout, P.W., Dunn, B.P. and Beer, C.T.  Effects of acronycine on nucleic acid synthesis and population growth in mammalian tumor cell cultures.  J. Cell. Physiol. 78: 127 (1971).

 

2.         Dunn, B.P., Gout, P.W. and Beer, C.T.  Effects of the antineoplastic alkaloid acronycine on nucleoside uptake and incorporation into nucleic acids by cultured L5178Y cells.  Cancer Res. 33: 2310- (1973).

 

3.         Dunn, B.P. and Stich, H.F.  The use of mussels in estimating benzo(a)pyrene contamination of the marine environment.  Proc. Soc. Exp. Biol. Med. 150: 49-51 (1975).

 

4.         Stich, H.F., Acton, A.B. and Dunn, B.P.  Carcinogens in estuaries, their monitoring and possible hazard to man.  In:  Environmental Pollution and Carcinogenic Risks, C. Rosenfeld and W. Davis (eds), INSERM Symp. Ser. Vol. 52/IARC Sci. Publ. No. 13, INSERM, Paris, pp. 83-94 (1976).

 

5.         Dunn, B.P. and Stich, H.F.  Release of the carcinogen benzo(a)pyrene from environmentally contaminated mussels.  Bull. Environ. Contam. Toxicol. 15: 398-401 (1976).

 

6.         Dunn, B.P.  Techniques for determination of benzo(a)pyrene in marine organisms and sediments.  Environ. Sci. Technol. 10: 1018-1021 (1976).

 

7.         Dunn, B.P. and Stich, H.F.  Monitoring procedures for chemical carcinogens in coastal waters.  J. Fish. Res. Board Can. 33: 2040-2046 (1976).

 

8.         Dunn, B.P. and Young, D.R.  Baseline levels of benzo(a)pyrene in southern California mussels.  Mar. Pollut. Bull. 7: 231-234 (1976).

 

9.         Stich, H.F., Acton A.B., Dunn, B.P., Oishi, K., Yamazaki, F., Harada, T., Peters, G. and Peters, N.  Geographic variations in tumor prevalence among marine fish populations.  Int. J. Cancer 20: 780-791 (1977).

 

10.        Dunn, B.P. and Fee, J.  Polycyclic aromatic hydrocarbons in commercial seafoods.  J. Fish. Res. Board Can. 36: 1469-1476 (1979).

 

11.        Dunn, B.P.  Determination of PAHs in marine samples by liquid chromatography.  Chromatogr. Newslett. 8: 10-12 (1980).

 

12.        Dunn, B.P.  Polycyclic aromatic hydrocarbons in marine sediments, bivalves, and seaweeds:  analysis by high pressure liquid chromatography.  In:  Polynuclear Aromatic Hydrocarbons:  Chemistry and Biological Effects, A. Bjorseth and A.J. Dennis (eds), Battelle Press, Columbus, OH, pp. 367-377 (1980).

 

13.        Farrington, H.W., Albaiges, J., Burns, K., Dunn, B.P., Eaton, P., Laseter, J.L., Parker, P.L. and Wise, S.  Fossil fuels.  In:  The International Mussel Watch, National Academy of Sciences, Washington D.C., pp. 7-77 (1980).

 

14.        Dunn, B.P.  Benzo(a)pyrene in the marine environment:  analytical techniques and results.  In:  Hydrocarbons and Halogenated Hydrocarbons in the Aquatic Environment, B.K. Afghan and D. Mackay (eds), Plenum Press, New York, pp. 109-119 (1980).

 

15.        Dunn, B.P. and Armour, R.J.  Sample extraction and purification for determination of polycyclic aromatic hydrocarbons by reversed phase chromatography.  Anal. Chem. 52: 2027-2031 (1980).

 

16.        Stich, H.F. and Dunn, B.P.  The carcinogenic load of the environment:  benzo(a)pyrene in sediments of Arctic waters.  Arctic 33: 807-814 (1980).

 

17.        Stich, H.F., Dunn, B.P., Acton, A.B., Yamasaki, F., Oishi, K. and Harada, T.  The distribution of benzo(a)pyrene in bottom sediments and of neoplasms in bottom-dwelling flatfish species of the Pacific and Atlantic Oceans, North, China, Bering, and Beaufort Seas, and Sea of Okhotsk.  In:  Carcinogenic Polynuclear Aromatic Hydrocarbons in the Marine Environment, N.L. Richards and B.L. Jackson (eds), EPA-600/9-82-013, Environmental Research Laboratory, U.S. Environmental Protection Agency, Gulf Breeze, FL, pp. 244-259 (1982).

 

18.        Dunn, B.P.  Polycyclic aromatic hydrocarbons.  In:  Carcinogens and Mutagens in the Environment, Vol. I, Food Products, H.F. Stich (ed.), CRC Press, Boca Raton, FL, pp. 175-183 (1982).

 

19.        Dunn, B.P.  Binding of orally administered benzo(a)pyrene to the DNA of mice over a dosage range of 100,000.  In:  Polynuclear Aromatic Hydrocarbons:  Physical and Biological Chemistry, M. Cooke, A.J. Dennis and G.L. Fisher (eds), Battelle Press, Columbus, OH, pp. 247-254 (1982).

 

20.        Hanham, A.F., Dunn, B.P. and Stich, H.F.  Clastogenic activity of caffeic acid and its relationship to hydrogen peroxide generated during autooxidation.  Mutation Res. 116: 333-339 (1983).

 

21.        Dunn, B.P.  Determination of PAH in sediments and marine organisms.  In:  Handbook of Polycyclic Aromatic Hydrocarbons, A. Bjorseth (ed.), Marcel Dekker, New York, pp. 439-459 (1983).

 

22.        Dunn, B.P.  Wide-range linear dose-response curve for DNA binding of orally administered benzo(a)pyrene in mice.  Cancer Res. 43: 2654-2658 (1983).

 

23.        Dunn, B.P. and Stich, H.F.  Determination of free and protein-bound N-nitrosoproline in nitrite-cured meat products.  Food Chem. Toxicol. 22: 609-613 (1984).

 

24.        Stich, H.F., Hornby, A.P. and Dunn, B.P.  The effect of dietary factors on nitrosoproline levels in human urine.  Int. J. Cancer 33: 625-628 (1984).

 

25.        Stich, H.F., Dunn, B.P., Pignatelli, B., Ohshima, H. and Bartsch, H.  Dietary phenolics and betel nut extracts as modifiers of N-nitrosation in rat and man.  In:  N-Nitroso Compounds:  Occurrence, Biological Effects and Relevance to Human Cancer, I.K. O'Neill, R.C. von Borstel, C.T. Miller, J. Long and H. Bartsch (eds), IARC Sci. Publ. No. 57, International Agency for Research on Cancer, Lyon, pp. 213-222 (1984).

 

26.        Curtis, J.R. and Dunn, B.P.  High pressure liquid chromatography for isolation of clastogenic agents from urine.  Mutation Res. 147: 171-177 (1985).

 

27.        Dunn, B.P. and Curtis, J.R.  Clastogenic agents in the urine of coffee drinkers and cigarette smokers.  Mutation Res. 147: 179-188 (1985).

 

28.        Stich, H.F., Hornby, A.P. and Dunn, B.P.  A pilot beta-carotene intervention trial with Inuits using smokeless tobacco.  Int. J. Cancer 36: 321-327 (1985).

 

29.        Stich, H.F., Hornby, A.P. and Dunn, B.P.  Beta-carotene levels in exfoliated mucosa cells of population groups at low and elevated risk for oral cancer.  Int. J. Cancer 37: 389-393 (1986).

 

30.        Stich, H.F., Hornby, A.P. and Dunn, B.P.  Beta-carotene levels in exfoliated human mucosa cells following its oral administration.  Cancer Lett. 30: 133-141 (1986).

 

31.        Dunn, B.P. and Stich, H.F.  32P-Postlabelling analysis of aromatic DNA adducts in human oral mucosal cells.  Carcinogenesis 7: 1115-1120 (1986).

 

32.        Stich, H.F. and Dunn, B.P.  Relationship between cellular levels of beta-carotene and sensitivity to genotoxic agents.  Int. J. Cancer 38: 713-717 (1986).

 

33.        Rosin, M.P., Dunn, B.P. and Stich, H.F.  Use of intermediate endpoints in quantitating the response of precancerous lesions to chemopreventive agents.  Can. J. Physiol. Pharmacol. 65: 483-487 (1987).

 

34.        Dunn, B.P., Black, J.J. and Maccubbin, A.  32P-Postlabeling analysis of aromatic DNA adducts in fish from polluted areas.  Cancer Res. 47: 6543-6548 (1987).

 

35.        Dunn, B.P.  High-energy orbit refueling for orbital transfer vehicles.  J. Spacecraft and Rockets 24: 518-522 (1987) (private research).

 

36.        Dunn, B.P. and San, R.H.C.  HPLC enrichment of hydrophobic DNA-carcinogen adducts for enhanced sensitivity of 32P-postlabeling analysis.  Carcinogenesis 9: 1055-1060 (1988).

 

37.        Stich, H.F. and Dunn, B.P.  DNA adducts, micronuclei and leukoplakias as intermediate endpoints in intervention trials.  In:  Methods for Detecting DNA Damaging Agents in Humans:  Applications in Cancer Epidemiology and Prevention, H. Bartsch, K. Hemminki and I.K. O'Neill (eds), IARC Sci. Publ. No. 89, International Agency for Research on Cancer, Lyon, pp. 137-145 (1988).

 

38.        San, R.H.C., Rosin, M.P., See, R.H., Dunn, B.P. and Stich, H.F.  Use of urine for monitoring human exposure to genotoxic agents.  In:  Biological Monitoring for Pesticide Exposure, R.G.M. Wang, C.A. Franklin, R.C. Honeycutt and J.C. Reinert (eds), ACS Symp. Ser. No. 382, American Chemical Society, Washington D.C., pp. 98-116 (1989).

 

39.        Dunn, B.P.  Detection of aromatic DNA adducts in human cells and fish liver.  J. Am. Coll. Toxicol. 8: 905-912 (1989).

 

40.        Dunn, B.P.  DNA-carcinogen adducts in fish as a tool for measuring the effective biological dose of aquatic carcinogens.  In:  In Situ Evaluations of Biological Hazards of Environmental Pollutants, Plenum Publ. Corp., pp. 177-181 (1990).

 

41.        Maccubbin, A.E., Black, J.J. and Dunn, B.P.  32P-Postlabeling detection of DNA adducts in fish from chemically contaminated waterways.  Sci. Total Env. 94:89-104 (1990).

 

42.        See, R.H., Dunn, B.P. and San, R.H.C.  Clastogenic activity in urine of workers occupationally exposed to pesticides.  Mutation Res., 241: 251-259 (1990).

 

43.        Metcalfe, C.D., Balch, G.C., Cairns, V.W., Fitzsimons, J.D. and Dunn, B.P.  Carcinogenic and Genotoxic Activity of Extracts from Contaminated Sediments in Western Lake Ontario.  Sci. Total Env. 94:125-141 (1990).

 

44.        Dunn, B.P.  DNA Adducts: Environmental Exposures.  Toxicology Forum, Summer Meeting (1990).

 

45.        Dunn, B.P.  Carcinogen adducts as an indicator for the public health risks of consuming carcinogen-exposed fish and shellfish.  Environ. Health Perspect., 90:111-116 (1991).

 

46.        Ray, S. Dunn, B.P., Payne, J.F., Fancey, L., Helbig, R. and Beland, P.  Aromatic DNA-carcinogen adducts in Beluga whales from the Canadian Arctic and Gulf of St Lawrence.  Marine Pollution Bulletin 22: 392-396 (1991).

 

47.        Rousseau, E., Davison, A. and Dunn, B.  Protection by beta-carotene against photochemical damage and singlet state oxygen.  Trends in Photochemistry and Photobiology, pp. 259-264 (1991).

 

48.        Hornby, A.P., Leichter, J. and Dunn, B.P.  The influence of chronic ethanol ingestion on the absorption of Vitamin A by adult male rats.  Nutrition Research 11: 231-238 (1991).

 

49.        Dunn, B.P., Vedal, S., San, R.H.C., Kwan, W.F., Nelems, B. Enarson, D.A. and Stich, H.F.  DNA adducts in Bronchial Biopsies  Int. J. Cancer 48: 485-92 (1991).

 

50.        Leichter J., Dunn. B.P. and Hornby, A.P.  Liver Vitamin A levels in the rat fetus and dam after chronic maternal alcohol consumption.  Biochemical Archives, 7: 261-267 (1991).

 

51.        Leichter, J., McNeill, J.H., Basu, T.K. and Dunn, B.P.  Influence of insulin on plasma and liver Vitamin A levels in diabetic rats.  J. Clinical Biochemistry and Nutrition 11: 47-52 (1991).

 

52.        Rousseau, E., Davison, A. and Dunn, B.  Protection by beta-carotene and related compounds against oxygen mediated cytotoxicity and genotoxicity: implications for carcinogenesis and anticarcinogenesis.  Free Radicals in Biology and Medicine 13: 407-433 (1992)

 

53.        Leichter, J and Dunn, B.P.  Effect of beta-carotene supplementation on fetal growth of rats who are exposed to cigarette smoke during pregnancy.  Biochem. Archives.  8:197-204 (1992).

 

54.        Rousseau, E., Davison, A. and Dunn, B.  Protection by beta-carotene against photochemical damage and singlet state oxygen.  Trends in Photochem. and Photobiol. 1: 259-264 (1993).

 

55.        Davison, A., Rousseau, E., and Dunn, B.  Putative anticarcinogenic actions of beta-carotene: nutritional implications.  Canad. J.  Physiol. Pharmacol. 71:732-745 (1993).

 

56.        Skinner, M, Jones, K.E. and Dunn, B.P.  Undetectability of vitamin A in bee brood  Apidologie 26, 1-8 (1995).

 

57.        Hofseth LJ. Dunn BP. Rosin MP. Micronucleus frequencies in urothelial cells of catheterized patients with chronic bladder inflammation. Mutation Research. 352(1-2):65-72, 1996 Jun 10.

 

58.        Wasan KM. Ramaswamy M. Haley J. Dunn BP. Administration of long-term tamoxifen therapy modifies the plasma lipoprotein-lipid concentration and lipid transfer protein I activity in postmenopausal women with breast cancer. Journal of Pharmaceutical Sciences. 86(7):876-9, 1997 Jul.

 

59.        Borugian MJ. Sheps SB. Kim-Sing C. Olivotto IA. Van Patten C. Dunn BP. Coldman AJ. Potter JD. Gallagher RP. Hislop TG. Waist-to-hip ratio and breast cancer mortality. American Journal of Epidemiology. 158(10):963-8, 2003 Nov 15.

 

60.        Borugian MJ. Sheps SB. Kim-Sing C. Van Patten C. Potter JD. Dunn B. Gallagher RP. Hislop TG. Insulin, macronutrient intake, and physical activity: are potential indicators of insulin resistance associated with mortality from breast cancer?.  Cancer Epidemiology, Biomarkers & Prevention. 13(7):1163-72, 2004 Jul.

 

 

Abstracts

 

1.         Dunn, B.P., Gout, P.W. and Beer, C.T.  Inhibition of population growth and nucleic acid synthesis in cultures of L5178Y and IRC cells by acronycine.  Proc. Am. Assoc. Cancer Res. 12: No. 216 (1971).

 

2.         Gout, P.W., Dunn, B.P. and Beer, C.T.  Effect of acronycine on nucleic acid synthesis and precursor uptake by L5178Y cells.  Fed. Proc. 31: No. 3663 (1972).

 

3.         Dunn, B.P. and Stich, H.F.  The use of accumulator organisms in a monitoring system for chemical carcinogens in coastal waters.  Proc. 13th Pacific Science Congress 1: 20 (1975).

 

4.         Dunn, B.P. and Stich, H.F.  Detection of carcinogen-DNA adducts in human oral mucosal cells.  Third Terry Fox Cancer Conference on Cancer Prevention: Theory and Practice, Vancouver, B.C., 12-14 August (1985).

 

5.         Maccubbin, A.E., Black, J.J. and Dunn, B.P.  32P-Postlabeling detection of aromatic carcinogen:DNA adducts in liver from fish from polluted areas.  Proc. Am. Assoc. Cancer Res. 28: No. 402 (1987).

 

6.         Dunn, B.P. and San, R.H.C.  High pressure liquid chromatography coupled with 32P-postlabeling analysis for the analysis of aromatic DNA-carcinogen adducts in human and animal tissues exposed to environmental carcinogens.  32nd Annual Meeting of the Genetics Society of Canada, Saskatoon, Sask., 14-18 June (1987).

 

7.         San, R.H.C., See, R.H. and Dunn, B.P.  Clastogenic activity in the urine of workers occupationally exposed to pesticides.  32nd Annual Meeting of the Genetics Society of Canada, Saskatoon, Sask., 14-18 June (1987).

 

8.         Dunn, B.P., Black, J.J. and Maccubbin, A.E.  32P-Postlabeling detection of aromatic DNA-carcinogen adducts in fish from PAH contaminated rivers.  11th International Symposium on Polynuclear Aromatic Hydrocarbons, Gaithersburg, MD, 23-25 September (1987).

 

9.         Maccubbin, A.E., Black, J.J. and Dunn, B.P.  32P-Postlabeling detection of DNA adducts in fish from chemically contaminated waterways.  14th Annual Aquatic Toxicity Workshop, Toronto, Ont., 1-4 November (1987).

 

10.        Dunn, B.P. and San, R.H.C.  High pressure liquid chromatography vs. nuclease P1 for enhancement of 32P-postlabeling analysis of aromatic DNA-carcinogen adducts.  Proc. Am. Assoc. Cancer Res. 29: No. 385 (1988).

 

11.        Dunn, B.P.  Postlabeling detection of adducts in fish livers from polluted habitats.  International Conference on Fish Health, American Fisheries Society, Vancouver, B.C., 19-21 July (1988).

 

12.        Dunn, B.P., Stich, H.F. and Vedal, S.  Aromatic DNA adducts in the lungs of smokers.  Proc. Am. Assoc. Cancer Res. 30: No. 510 (1989).

 

13.        Dunn, B.P., Payne, J.F., Ray, S. and Halbrook, R.S.  Aromatic DNA adducts in fish and marine mammals from polluted and unpolluted waters.  Environ. Mol. Mutagen. 15 (Suppl. 17): 17 (1990).

 

14.        Dunn, B.P., Fitzsimons, J., Stalling, D., Maccubbin, A.E. and Black, J.J.  Pollution-related aromatic DNA adducts in liver from populations of wild fish.  Proc. Am. Assoc. Cancer Res. 31: 96 (1990).

 

15.        Vedal, S., Dunn, B.P., Enarson, D.A. and Stich, H.F.  Aromatic bronchial DNA adducts: Effects of cigarette smoking, diet and lung cancer.  1990 World Conference on Lung Health, 1990.

 

16.        Dunn, B.P.  DNA-carcinogen adduct in aquatic organisms.  17th Annual Aquatic Toxicity Workshop Vancouver B.C. Nov 5-7 (1990).

 

17.        Dunn, B.P. and Douglas, G.R.  DNA adducts in cells treated with 1-methylphenanthrene.  Proc. Am. Assoc. Cancer Res. 32 (1991).

 

18.        Dunn, B.P. and Hosseini, A.  International variations in breast cancer incidence.  Effect of diet and age at first marriage.  Proc. Am. Assoc. Cancer Res. 34 (1993).

 

19.        Dunn, B.P.  Time Dependence of the Relationship between Diet and Breast Cancer in 34 Countries.  American Institute for Cancer Research, Washington D.C.  Sept. 2-3 (1993).

 

20.        Dunn, B.P.  Time lag  for the effect of diet on breast cancer incidence in an international correlation study., Proc. Am. Assoc. Cancer Res. 35, p 295 (1994)

 

21.        Kao, J., Dunn, B and Wasan, K.M.  Influence of Chronic Tamoxifen Therapy on Lipoprotein-Lipid Composition in Post-menopausal Women with Breast Cancer.  Amer. Assoc. of Pharmaceutical Scientists, 10th Annual Meeting, Seattle, Washington Oct 27-31 (1996).

 

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